Yes - upload your CRM within the Audience Builder.

The platform can send ads to the mobile and desktop locations connected to specific email addresses. For instance, if you have a list of customers from Point of Sale data or a list of email subscribers to a newsletter, we can use those email addresses to identify the phones and computers where ads can be served. This allows you to run specific campaigns targeting these audiences (e.g., “Thank you for being our customer, come visit us again!”). Ideally, you'd have a minimum of 1000 addresses to help the data populate. Those addresses are cross-checked with our provider databases to validate them and find an associated IP address.  The ones that have a linked IP address that also appear in the provider database will be served an ad.  It is possible that not all of the people on the email list you provide will see an ad.